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KMID : 0352720070310020069
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Journal of Ginseng Research
2007 Volume.31 No. 2 p.69 ~ p.73
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Ginsentology II : Chemical Structure-Biological Activity Relationship of Ginsenoside
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Lee Byung-Hwan
Nah Seung-Yeol
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Abstract
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Since chemical structures of ginsenoside as active ingredient of Panax ginseng are known, accumulating evidences have shown that ginsenoside is one of bio-active ligands through the diverse physiological and pharmacological evaluations. Chemical structure of ginsenoside could be divided into three parts depending on diol or triol ginsenoside: Steroid- or cholesterol-like backbone structure, carbohydrate portions, which are attached at the carbon-3, -6 or -20, and aliphatic side chain coupled to the backbone structure at the carbon-20. Ginsenosides also exist as stereoisomer at the carbon-20. Bioactive ligands usually exhibit the their structure-function relationships. In ginsenosides, there is little known about the relationship of chemical structure and biological activity. Recent reports have shown that ginsenoside Rg₃, one of active ginsenosides, exhibits its differential physiological or pharmacological actions depending on its chemical structure. This review will show how ginsenoside Rg₃, as a model compound, is functionally coupled to voltage-gated ion channel or ligand-gated ion channel regulations in related with its chemical structure
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KEYWORD
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Panax ginseng, Ginsenoside Rg3, Bioactive ligand, Ion channels, Receptors, Structure-activity relationships
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